PRIM3D

The platform

Design and additive manufacturing

Based at Hôpital Broussais (AP-HP), PRIM3D brings together 3D design workstations, image- capture tools (3D cameras), and a fleet of manufacturing machines (FDM, SLA, polyjet, silicone printers), operated by engineers specialized in 3D design and manufacturing, backed by AP-HP's vast data bank (medical imaging, photographs).

The platform designs and 3D-prints organ replicas to prepare for complex surgeries, training simulators for caregivers, and custom-made spare parts to repair obsolete medical equipment. It now extends beyond the hospital, selling prototypes internationally and opening up to startups and manufacturers.

It aims to become, in time, AP-HP's in-house medical-device production center, addressing patient needs for which no industrial solution exists or is suitable — a project accompanied by regulatory approvals currently underway.

PRIM3D also coordinates the CHU 3D Network, which brings together the 3D-printing platforms of French university hospitals around two projects: harmonizing their clinical and technical practices, and creating a single point of contact to route requests between hospitals. The network held its first major national gathering in 2026 (seeEvents).

It was born in spring 2020, under Prof. Roman Khonsari's responsibility, as an emergency 3D-printing workshop set up in the Port-Royal abbey cloister (Hôpital Cochin) to quickly address shortages of medical equipment and protective gear for caregivers during the first wave of COVID-19 — a story told in the book Emergency Medical 3D Printing (seePublications).

Team

Who runs PRIM3D

Delphine Prieur

Operational Director

PhD, MBA.

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Roman Hossein Khonsari

Medical and Scientific Director

Maxillofacial surgeon, Necker - Enfants malades Hospital; head of the Forme et Croissance du Crâne lab.

François Simon

Educational Lead

Lionel Tortolano

Medical Devices Lead

Florence Baguet

Director of Finance and Technology Platforms, DRCI

Ayoub Yezid

Quality Lead

Engineers

Juliette Prébot

R&D Lead Engineer

Lisa Viallon

CAD/CAM Engineer

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Léo Moncorgé

CAD/CAM Engineer

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Engineering interns

Théo Montzikian

Thomas Petit

Marion Frohly

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Thomas Brancherau

PhD students

Maxime Duvelleroy

PhD student, engineer

Lucia Charlaix

PhD student, physician

Visiting M2 research physicians

Louis Vaisière

Chloé David

Alice Brochier

Juliette Antraygues

Former members

Maël Duportal

Engineer

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Florent Bousquié

Contributed to structuring PRIM3D, from the Covid project to the platform, as the link with AP-HP's leadership.

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Research

Publications

• Validation of a 3D-Printed Multimaterial Transcanal Tympanoplasty Simulator for Endoscopic Ear Surgery.

  Rançon S, Prebot J, Denoyelle F, Khonsari RH, Simon F.

  Otol Neurotol. 2025 Sep 1;46(8):e323-e329. doi: 10.1097/MAO.0000000000004546. Epub 2025 Jun 2.

• How are stomas managed in low- and lower-middle income countries?

  Charlaix AL, De Ponthaud C, Capito C, Viallon L, Prieur D, Khonsari RH, Gaujoux S.

  BJS. 2025;112(Supplement_15):xv62-xv64. doi: 10.1093/bjs/znaf218.

• Development of 3D-printed female genital models to improve consent, education, and medico-legal communication.

  Viallon L, Liautard M, Harmel C, Gorgiard C, Cuillière V, Prieur DS, Deguette C, Dufayet L.

  Med Teach. 2025 Dec 21. doi: 10.1080/0142159X.2025.2603354. Online ahead of print.

• Quality versus emergency: How good were ventilation fittings produced by additive manufacturing to address shortages during the COVID19 pandemic?

  Khonsari RH, Oranger M, François PM, Mendoza-Ruiz A, Leroux K, Boussaid G, Prieur D, Hodge JP, Belle A, Midler V, Morelot-Panzini C, Patout M, Gonzalez-Bermejo J.

  PLoS One. 2022 Apr 21;17(4):e0263808. doi: 10.1371/journal.pone.0263808. eCollection 2022.

• In-house 3D printing: Why, when, and how? Overview of the national French good practice guidelines for in-house 3D-printing in maxillo-facial surgery, stomatology, and oral surgery.

  Khonsari RH, Adam J, Benassarou M, Bertin H, Billotet B, Bouaoud J, Bouletreau P, Garmi R, Gellée T, Haen P, Ketoff S, Lescaille G, Louvrier A, Lutz JC, Makaremi M, Nicot R, Pham-Dang N, Praud M, Saint-Pierre F, Schouman T, Sicard L, Simon F, Wojcik T, Meyer C; French Society of Stomatology, Maxillo-Facial Surgery and Oral Surgery (SFSCMFCO).

  J Stomatol Oral Maxillofac Surg. 2021 Sep;122(4):458-461. doi: 10.1016/j.jormas.2021.08.002. Epub 2021 Aug 13.

• 3D-printed contact-free devices designed and dispatched against the COVID-19 pandemic: The 3D COVID initiative.

  François PM, Bonnet X, Kosior J, Adam J, Khonsari RH.

  J Stomatol Oral Maxillofac Surg. 2021 Sep;122(4):381-385. doi: 10.1016/j.jormas.2020.06.010. Epub 2020 Jun 26.

• 3D-printed shields for slit lamps produced during the COVID-19 pandemic.

  Delbarre M, François PM, Adam J, Caruhel JB, Froussart-Maille F, Khonsari RH.

  Ann 3D Print Med. 2021 Mar;1:100004. doi: 10.1016/j.stlm.2020.100004. Epub 2021 Mar 19.

• 3D-printed suture guide for thoracic and cardiovascular surgery produced during the COVID19 pandemic.

  Laliève L, Adam J, Nataf P, Khonsari RH.

  Ann 3D Print Med. 2021 Mar;1:100005. doi: 10.1016/j.stlm.2020.100005. Epub 2021 Mar 19.

• Implementation of a digital chain for the design and manufacture of implant-based surgical guides in a hospital setting.

  Pajot T, Benichou L, Moreau E, Tallon V, Meningaud JP, Khonsari RH, Ketoff S.

  J Stomatol Oral Maxillofac Surg. 2020 Sep;121(4):347-351. doi: 10.1016/j.jormas.2019.09.009. Epub 2019 Oct 5.

See all our publications →

Find us

The platform

Bâtiment Ady Steg AP-HP
8 rue Maria Helena Vieira Da Silva, 75014 Paris, France

Origins

COVID devices from the initial platform

Illustrations by Emma Blanc-Tailleur of four devices designed and 3D-printed during the first wave of COVID-19, before PRIM3D was created.