Research
Projects
Growth and biomechanics of the craniocervical junction
Geometric modeling of the normal growth of the craniocervical junction (age 0-18) and its anatomy/mobility in adults, with applications to FGFR-related malformations.
Craniofacial growth in achondroplasia
A multimodal 3D study of craniofacial growth and function in patients with achondroplasia.
Emma Jourdain, Roman Hossein Khonsari, Anne Morice, Maxime Taverne
Non-invasive ventilation and facial phenotype
Evaluation of the forces applied by non-invasive ventilation devices (CPAP masks) on the pediatric facial phenotype in patients with syndromic craniosynostoses due to FGFR mutations, and their long-term clinical consequences.
Sonia Khirani, Margaux Ntirubuza, Aloïs Roussel, Maxime Taverne, Yehong Zhong
Normal and pathological mandibular growth
Normal and pathological mandibular growth, accounting for the role of teeth and building a morphological space.
Multi-scale modeling of sutures and synchondroses
Multi-scale modeling of how cranial sutures and synchondroses function.
Emilie Dambroise, Nicolas Kogane, Sébastien Laporte, Maxime Taverne
Brain shape in syndromic craniosynostoses
Description of brain shape in syndromic craniosynostoses.
Ombline Delassus, David Germanaud, JF Mangin
Symbolic modeling of craniofacial growth
Formalization of current skull-growth theories using ontologies and machine learning (Victoria Franchetti-Romero's PhD thesis, 2026-2029).
John Baxter, Victoria Franchetti-Romero, Pierre Jannin, Roman Hossein Khonsari, Maxime Taverne
![Outs[AI]der](/projects/outsaider-artwork.jpg)
Outs[AI]der
International data-science challenge (Health Data Hub / France 2030) with GHU Paris Psychiatrie et Neurosciences and Necker - Enfants malades Hospital: applying computational methods to the MAHHSA museum's art brut collection, comparing it against a corpus of modern and contemporary art. Three questions guide the study: can these methods distinguish art brut from a conventional corpus? Can distinct formal characteristics be identified independently of any clinical hypothesis? Are some of these characteristics correlated with clinical parameters?
Marin Chapelle, Parand Danesh, Anne-Marie Dubois, Raphaël Gaillard, Roman Hossein Khonsari, Julie Tang
FaceWorld
Self-perception in children with rare craniofacial malformations, a France/Ukraine comparative study combining medicine, art, and psychology.
Charlotte Jacquemot, Roman Hossein Khonsari, Tetyana Pavlychuk
Socioface
A conversational agent built with Bayes Impact and Google's open-source Gemma tool to help families of children with craniofacial malformations navigate medico-social procedures, in connection with the Filière Santé Maladies Rares TETECOU, the CRMR MAFACE and CRANIOST reference centers, ERN CRANIO, and the Les P'tits Courageux association. Developed as part of the Impulse Healthcare program (AP-HP), presented at the Bayes Impact Demo Day on 1 July 2026 at Hôtel-Dieu, under the high patronage of the President of the Republic. The agent informs and orients without ever giving a diagnosis or replacing a doctor or social services.
BounTI: AI-based automatic segmentation of skull bones
Development and application of BounTI (Boundary-preserving Threshold Iteration), an open-source algorithm for automatic segmentation of calcified tissues by iterative thresholding, to skull bone segmentation.
Moé Moisson, Khosrow Rajabizadeh, Maxime Taverne, Maxime Donzel
Craniofacial phenotyping of animal models and craniofacial malformations
A platform-style service offering advanced craniofacial phenotyping, drawing on the lab's tools and methods both for technical questions and for the study of murine models (mice, zebrafish), in collaboration with Institut Imagine.